论文部分内容阅读
目的探讨高频振荡通气治疗新生儿呼吸窘迫综合征的临床疗效。方法选择2011年4月—2014年4月收治的新生儿呼吸窘迫综合征患儿50例,随机分为对照组和治疗组各25例。对照组采用常频机械通气模式治疗,治疗组采用高频振荡通气模式治疗,观察两组患儿临床疗效、血气分析结果及并发症发生情况。计量资料采用t检验,计数资料采用χ2检验,P<0.05为差异有统计学意义。结果治疗组总有效率(84.0%)明显高于对照组(56.0%),差异有统计学意义(χ2=4.667,P<0.05)。治疗组患儿p H值、Pa O[(7.672±0.06)、(89±19)mm Hg(1 mm Hg=0.133 k Pa)]明显高于对照组[(7.32±0.09)、(40±10)mm Hg];治疗组Pa CO2和氧合指数(oxygen index,OI)[(41±9)mm Hg、(16±4)]明显低于对照组[(54±12)mm Hg、(25±5)],差异均有统计学意义(均P<0.05)。治疗组并发气胸、肺气漏及慢性肺疾病5例,占20.0%,明显低于对照组的12例(48.0%),差异有统计学意义(χ2=4.367,P<0.05)。结论高频振荡通气治疗新生儿呼吸窘迫综合征安全有效,不良反应少,临床疗效显著,具有较高的临床推广价值。
Objective To investigate the clinical effect of high frequency oscillatory ventilation on neonatal respiratory distress syndrome. Methods 50 cases of neonatal respiratory distress syndrome admitted from April 2011 to April 2014 were randomly divided into control group and 25 cases in treatment group. The control group was treated by the mode of frequent mechanical ventilation. The treatment group was treated by high-frequency oscillatory ventilation. The clinical curative effect, blood gas analysis results and complication of the two groups were observed. Measurement data using t test, count data using χ2 test, P <0.05 for the difference was statistically significant. Results The total effective rate (84.0%) in the treatment group was significantly higher than that in the control group (56.0%), the difference was statistically significant (χ2 = 4.667, P <0.05). The values of p H, Pa O (7.672 ± 0.06), (89 ± 19) mm Hg (1 mm Hg = 0.133 kPa)] in the treatment group were significantly higher than those in the control group [(7.32 ± 0.09), (40 ± 10) ) mm Hg]; PaCO 2 and oxygen index (OI) in the treatment group [(41 ± 9) mm Hg, (16 ± 4)] were significantly lower than those in the control group [(54 ± 12) mm Hg, ± 5)], the differences were statistically significant (all P <0.05). The treatment group had pneumothorax, pulmonary air leak and chronic lung disease in 5 cases (20.0%), which was significantly lower than that in the control group (12%, 48.0%). The difference was statistically significant (χ2 = 4.367, P <0.05). Conclusions High-frequency oscillatory ventilation is safe and effective in neonatal respiratory distress syndrome, with few adverse reactions and significant clinical effects, which has a high clinical value.