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目的探讨枸橼酸咖啡因与氨茶碱治疗早产儿原发性呼吸暂停的疗效。方法 80例原发性呼吸暂停早产儿入院后被分为两组,对照组(40例)给予氨茶碱治疗,观察组(40例)给予枸橼酸咖啡因治疗,依据治疗后的疗效、原发性呼吸暂停的发作次数和消失时间及治疗期间不良反应发生情况,评价枸橼酸咖啡因与氨茶碱治疗早产儿原发性呼吸暂停的疗效。结果观察组有效率85.0%,对照组有效率75.0%,观察组有效率明显更高,差异有统计学意义(P<0.05)。观察组呼吸暂停发生次数少于对照组,消失时间短于对照组,差异有统计学意义(P<0.05)。治疗期间,观察组患儿心动过速、喂养不耐受、支气管肺发育等不良反应率均低于对照组,差异有统计学意义(P<0.05)。结论与氨茶碱相比,枸橼酸咖啡因对早产儿原发性呼吸暂停具有较好的治疗效果,能快速降低呼吸暂停的发作频率,消除临床症状,具有较高的药物安全性,是理想的用于治疗原发性呼吸暂停的药物。
Objective To investigate the efficacy of citrate caffeine and aminophylline in the treatment of premature infants with primary apnea. Methods 80 cases of primary apnea preterm infants were divided into two groups after admission. The control group (40 cases) was given aminophylline, and the observation group (40 cases) was given citrate caffeine. According to the therapeutic effect, Primary apnea episodes and disappearance of time and adverse reactions during treatment, assessment of citrate caffeine and aminophylline in the treatment of premature children with primary apnea. Results The effective rate was 85.0% in the observation group and 75.0% in the control group, and the effective rate in the observation group was significantly higher (P <0.05). The number of apnea episodes in the observation group was less than that in the control group, and the disappearance time was shorter in the observation group than in the control group, with significant difference (P <0.05). During the treatment period, adverse reactions such as tachycardia, feeding intolerance and bronchopulmonary development in observation group were lower than those in control group, the difference was statistically significant (P <0.05). Conclusion Compared with aminophylline, citrate caffeine has a good therapeutic effect on premature infants with primary apnea, can quickly reduce the frequency of episodes of apnea, eliminate clinical symptoms, with high drug safety, is Ideal for the treatment of primary apnea drugs.