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目的评估奥曲肽对重症急性胰腺炎的治疗效果。方法将55例重症急性胰腺炎患者随机分成对照组和实验组。对照组予以常规方法治疗;实验组在常规方法基础上加用奥曲肽治疗。观察2组患者白细胞、血淀粉酶、血糖、血钙恢复正常时间和C反应蛋白变化,以及住院时间、并发症和死亡率的发生情况。结果实验组患者白细胞、血淀粉酶、血糖恢复正常时间明显短于对照组(P<0.05),C反应蛋白第4天和第7天明显低于对照组(P<0.05);实验组住院时间明显短于对照组(P<0.05);实验组和对照组并发症总发生率分别为51.7%和84.6%(P<0.05),死亡率分别为10.3%和34.6%(P<0.05)。结论重症急性胰腺炎早期应用奥曲肽不仅能改善患者的临床症状和生化指标,还能减轻全身炎症反应,降低多器官功能衰竭的发生,改善预后。
Objective To evaluate the therapeutic effect of octreotide on severe acute pancreatitis. Methods 55 cases of severe acute pancreatitis were randomly divided into control group and experimental group. The control group was treated by conventional method; the experimental group was treated with octreotide on the basis of routine methods. The leukocyte, blood amylase, blood glucose, serum calcium recovery time and C-reactive protein in two groups were observed, and the incidence of hospitalization, complications and mortality were observed. Results The leukocyte, blood amylase and blood glucose in the experimental group were significantly shorter than those in the control group (P <0.05), while the C-reactive protein in the fourth and seventh days was significantly lower than that of the control group (P <0.05) (P <0.05). The overall incidence of complications in experimental group and control group were 51.7% and 84.6% respectively (P <0.05), the mortality rates were 10.3% and 34.6% respectively (P <0.05). Conclusion The early application of octreotide in severe acute pancreatitis can not only improve the clinical symptoms and biochemical indexes, but also reduce the systemic inflammatory response, reduce the incidence of multiple organ failure and improve the prognosis.