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目的:研究多囊卵巢综合征(PCOS)血液血管内皮生长因子(VEGF)的表达,探讨VEGF在PCOS的发生发展中的作用。方法:应用ELISA测定PCOS组和对照组外周血清VEGF的浓度。结果:PCOS组血清VEGF水平明显高于正常对照组(P<0.001)。结论:VEGF可以促使卵泡周围血管生成,增加卵巢间质血管化,参与了PCOS的发生发展。
Objective: To investigate the expression of vascular endothelial growth factor (VEGF) in patients with polycystic ovary syndrome (PCOS) and to explore the role of VEGF in the development of PCOS. Methods: Serum levels of VEGF in PCOS group and control group were determined by ELISA. Results: Serum VEGF level in PCOS group was significantly higher than that in normal control group (P <0.001). Conclusion: VEGF can promote the formation of perivascularity of ovarian follicles, increase the vascularization of ovarian stroma and participate in the development of PCOS.