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目的研究转录因子Sp1在胃癌及正常胃黏膜组织中的表达特征,并探讨其与临床病理参数之间的关系。方法用免疫组织化学SP法,检测63例胃腺癌组织、19例胃黏膜不典型增生组织及10例因胃良性病变行部分切除的正常胃黏膜组织中Sp1的表达。结果Sp1在胃癌组织中的阳性表达率为59%,明显高于在胃黏膜不典型增生组织(21%)及正常胃黏膜组织(10%)中的表达率,差异具有统计学意义(P<0.05)。Sp1蛋白的表达与肿瘤的浸润深度及TNM分期、淋巴结转移密切相关。结论Sp1蛋白对胃癌的发生发展起重要作用,检测其蛋白表达水平对于评价患者的预后有一定价值。
Objective To investigate the expression of Sp1 in gastric cancer and normal gastric mucosa and to explore its relationship with clinical pathological parameters. Methods Immunohistochemical SP method was used to detect the expression of Sp1 in 63 cases of gastric adenocarcinoma, 19 cases of gastric mucosa dysplasia and 10 cases of gastric mucosa partially resected due to gastric benign lesions. Results The positive expression rate of Sp1 in gastric cancer was 59%, which was significantly higher than that in gastric atypical hyperplasia (21%) and normal gastric mucosa (10%), the difference was statistically significant (P < 0.05). The expression of Sp1 protein is closely related to the depth of tumor invasion, TNM stage and lymph node metastasis. Conclusion Sp1 protein plays an important role in the development and progression of gastric cancer. To detect the expression level of protein may be of value in evaluating the prognosis of patients.