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(一)抗生素类:1.青霉素的β—内酰胺环可使庆大霉素部分失活,从而降低庆大霉素疗效;2.与先锋Ⅱ号同用可增加对肾脏的毒性;3.与链霉素和卡那霉素均属氨基糖甙类抗生素,同用使毒性增加。(二)速尿或利尿酸钠。合用对耳毒性有协同作用。(三)在用乙醚或肌肉松弛剂尚未完全苏醒前同用可发生神经肌肉麻痹和呼吸抑制。(四)碳酸氢钠、氨茶硷等碱性药。凡能使尿液碱化的药物,均能使庆大霉素血药浓度峰值升高,半衰期延长,抗菌作用增强,毒性亦同时增加。若需同用时应减量。
(A) antibiotics: 1. Penicillin β-lactam ring can make gentamicin partially inactivated, thereby reducing the efficacy of gentamicin; 2. and Pioneer II with the same can increase the toxicity of the kidney; And streptomycin and kanamycin are aminoglycoside antibiotics, with the use of increased toxicity. (B) furosemide or sodium urate. Synergistic effect on ototoxicity. (C) in the use of ether or muscle relaxants have not fully awake before the same can occur with neuromuscular paralysis and respiratory depression. (D) sodium bicarbonate, aminophylline and other alkaline drugs. Where the alkalized urine drugs, can make gentamicin peak plasma concentration, half-life extension, enhanced antimicrobial effects, toxicity also increased. For the same use should be reduced.