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目的评价血清中胰岛素样生长因子-1(insulin-like growth factor 1,IGF-1)、胰岛素样生长因子结合蛋白-3(IGF bonding protein 3,IGFBP-3)水平和胰腺癌及大肠癌发生的关系。方法利用Meta分析法对20个关于血清IGF-1、IGFBP-3水平与胰腺癌、结肠癌及直肠癌的巢式病例对照研究进行综合分析。结果胰腺癌研究中,IGF-1合并OR值为1.07(95%CI:0.81~1.43),IGFBP-3合并OR值为1.00(95%CI:0.76~1.30);结肠癌研究中,IGF-1合并OR值为1.31(95%CI:1.07~1.59),IGFBP-3合并OR值为1.08(95%CI:0.90~1.30);直肠癌研究中,IGF-1合并OR值为0.85(95%CI:0.55~1.30),IGFBP-3合并OR值为0.88(95%CI:0.59~1.32)。结论血清IGF-1及IGFBP-3水平与胰腺癌和直肠癌的相关性无统计学意义;血清中高水平的IGF-1增加结肠癌发生的风险性,但是不存在IGFBP-3水平改变影响结肠癌发生的证据。
Objective To evaluate the serum levels of insulin-like growth factor 1 (IGF-1), insulin-like growth factor-binding protein-3 (IGFBP-3) and pancreatic cancer and colorectal cancer relationship. Methods A total of 20 nested case-control studies on serum IGF-1, IGFBP-3 levels and pancreatic cancer, colon cancer and rectal cancer were analyzed by Meta-analysis. Results In the study of pancreatic cancer, the OR of IGF-1 was 1.07 (95% CI: 0.81-1.43) and the OR of IGFBP-3 was 1.00 (95% CI: 0.76-1.30) The combined odds ratio (OR) was 1.31 (95% CI: 1.07-1.59), IGFBP-3 combined OR was 1.08 (95% CI: 0.90-1.30) : 0.55-1.30), IGFBP-3 combined OR was 0.88 (95% CI: 0.59-1.32). Conclusions The correlation between serum IGF-1, IGFBP-3 and pancreatic cancer and rectal cancer is not statistically significant. High levels of IGF-1 in serum increase the risk of colon cancer. However, there is no change in IGFBP-3 affecting colon cancer Evidence that occurred.