论文部分内容阅读
目的:探讨血管生成素样蛋白2(angiopoietin-like protein2,ANGPTL2)在食管鳞状细胞癌(esophageal squamous cell cancer,ESCC)组织中的表达及其临床意义。方法:采用免疫组化检测ESCC组织中ANGPTL2的表达水平;通过酶联免疫吸附法检测食管癌患者和健康对照人群血清中ANGPTL2浓度。结果:与癌旁组织相比,ESCC组织中ANGPTL2的表达明显升高(P<0.001);与健康对照人群相比,食管癌患者血清中ANGPTL2浓度明显升高。通过分析临床数据发现高表达的ANGPTL2与肿瘤体积、淋巴结转移、TNM分期紧密相关。血清ANGPTL2浓度也与淋巴结转移、TNM分期等呈正相关。结论:ANGPTL2在ESCC的增殖和侵袭过程中有重要作用。血清ANGPTL2可以作为诊断ESCC潜在有效的血清标志物。
Objective: To investigate the expression of angiopoietin-like protein 2 (ANGPTL2) in esophageal squamous cell carcinoma (ESCC) and its clinical significance. Methods: The expression of ANGPTL2 in ESCC tissues was detected by immunohistochemistry. The serum concentration of ANGPTL2 in esophageal cancer patients and healthy control subjects was detected by enzyme linked immunosorbent assay. Results: The expression of ANGPTL2 in esophageal squamous cell carcinoma was significantly higher than that in paracancerous tissues (P <0.001). Compared with healthy controls, serum ANGPTL2 levels in esophageal cancer patients significantly increased. Through analysis of clinical data, it was found that highly expressed ANGPTL2 was closely related to tumor volume, lymph node metastasis and TNM stage. The serum concentration of ANGPTL2 was also positively correlated with lymph node metastasis and TNM stage. Conclusion: ANGPTL2 plays an important role in the proliferation and invasion of ESCC. Serum ANGPTL2 can be used as a potentially useful serum marker in the diagnosis of ESCC.