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作者研究LAK细胞对粒-单核系祖细胞集落形成(CFU-GM)的影响,发现LAK细胞加骨髓细胞直接或孵育4h进行再培养,对CFU-GM无影响;孵育8,18h后可抑制CFU-GM,抑制率分别为27.4％(P<0.01)和50.5％(P<0.01);未活化的细胞则无影响。孵育4,8,18 h的清液抑制 CFU-GM更显著,分别为39.7％(P<0.01),51.7％(P<0.01)和72.5％(P<0.01)。该清液中还能测得干扰素活性效价,8和
The authors studied the effects of LAK cells on the colony formation of granulocyte-monocyte-derived progenitor cells (CFU-GM). It was found that LAK cells and myeloid cells were cultured directly or incubated for 4h and had no effect on CFU-GM. After 8 and 18 hours of incubation, CFU-GM, the inhibition rates were 27.4% (P <0.01) and 50.5% (P <0.01) respectively; the non-activated cells had no effect. The concentrations of CFU-GM at 4, 8 and 18 h after incubation were significantly higher (39.7%, 51.7% and 72.5%, respectively, P <0.01). The serum can also be measured interferon activity titers, 8 and