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锌与致畸动物实验表明:缺锌的母鼠受孕率下降,流产、早产和死产率均明显升高,严重者甚至可完全不孕;仔鼠的出生体重可低于正常仔鼠的一半,各种先天性畸形率高达98%。灵长类动物实验也有类似的报道。因此,锌缺乏对胚胎发育的影响是十分明显的。胚胎对锌的缺乏十分敏感,母体的短期缺锌就足以导致胎儿发育的严重而不可逆的变化。据Hurley等观察,当给孕鼠缺锌饲料时,仅需8天就可使46%的仔鼠出现多系统的先天性畸形,死产率高达13～15%。锌缺乏所致的先天性畸形可累及许多器官和系统:
Zinc and teratogenic animal experiments show that: zinc-deficient mother rats decreased conception rate, abortion, preterm birth and stillbirth rates were significantly increased, severe or even completely infertile; offspring of birth weight can be less than half of normal pups , A variety of congenital malformations up to 98%. Primate experiments are similarly reported. Therefore, the impact of zinc deficiency on embryonic development is very obvious. Embryos are very sensitive to the deficiency of zinc, and short-term zinc deficiency in the maternal body is sufficient to cause serious and irreversible changes in fetal development. According to Hurley et al., When giving zinc-deficient diets to pregnant rats, only 46% of pups became congenital malformations in multiple systems in just 8 days, with a stillbirth rate of 13-15%. Congenital malformations caused by zinc deficiency can affect many organs and systems: