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Ｔ细胞表面ＣＤ２８（受体）与ＡＰＣ细胞表面Ｂ７分子（配体）的结合似乎提供了Ｔ细胞激活所需的主要共刺激信号。共刺激信号是激发有效的细胞免疫应答所必须的，Ｂ７分子家族及ＣＤ２８／ＣＴＬＡ４等在共刺激信号的传递过程中起重要作用。肿瘤细胞表面不表达Ｂ７分子或
Binding of T cell surface CD28 (receptor) to APC cell surface B7 molecules (ligands) seems to provide the major co-stimulatory signal required for T cell activation. Co-stimulatory signals are necessary to elicit an effective cellular immune response. The B7 family and CD28/CTLA4 play an important role in the transmission of costimulatory signals. The surface of tumor cells do not express B7 molecules or