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目的 泡型包虫病(AE)是中国西部的一个重大公共卫生问题,在四川和青海2省藏族地区更为突出.多房棘球绦虫(E.multilocularis)是泡型包虫病的病原体.流行病学调查表明,犬是是泡型包虫病的显著流行风险因素,一些牧区犬只多房棘球绦虫感染率较高.这些研究表明犬可能作为终末宿主,在环境中维持多房棘球绦虫的生活史.但是普遍认为狐狸是环境中支撑多房棘球绦虫生活史的终末宿主.该研究旨在通过研究感染多房棘球绦虫犬只的空间聚集性,来进一步了解犬在环境中维持多房棘球绦虫生活史的证据.方法 在中国四川省西部青藏高原石渠县的牧区,通过氢溴酸槟榔碱驱虫的方法,收集家牧犬感染多房棘球绦虫感染状态,并用GPS测量这些犬只的地理位置数据.通过BB join - count test分析,了解感染多房棘球绦虫犬只是否存在空间聚集性.结果 在300 ～600、800、1600和1800～3900 m的距离,感染多房棘球绦虫犬只存在空间聚集性.结论 感染多房棘球绦虫犬只存在空间聚集性,表明环境中犬可能在多房棘球绦虫生活史中发挥作用.“,”Objective Alveolar echinococcosis (AE) is a major public health issue in western China,particularly in the Tibetan - Qinghai Plateau region of Sichuan and Qinghai Provinces.Echinococcus multilocularis (E.multilocularis) is the causative agent of AE.Epidemiology studies in this region indicated that dog related risk factors were significant for AE prevalence,the infection rates of E.multilocularis in dogs were high in some communities,these studies implied that dogs could have a role in the life cycle of E.multilocularis.But it is widely believed that foxes serve as definitive hosts in the life cycle of E.multilocularis.The research presented here was conducted to further understand that by investigating spatial clustering of E.multilocularis infected dogs in pastoral communities.Methods The study was done in pastoral communities of Tibetan - Qinghai plateau in western Sichuan province,China.E.multilocularis infection status in dogs was investigated by purging dogs using arecoline hydrobromide,and geographic location data of the dogs were collected by using GPS.The BB join count test was employed to determine if there was a positive spatial relationship among dogs infected with E.multilocularis.Results In the study area,there was spatial clustering among dogs infected with E.multilocularis with a join distance classes of 300 -600,800,1600 and 1800 -3 900 meters.Conclusion This research supports that dogs can contribute to the life cycle of E.multilocularis in the Tibetan - Qinghai plateau region of Sichuan province,China.