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多形性腺瘤是最常见的涎腺良性肿瘤,组织学上有多形性特征,即肿瘤性上皮组织与粘液样、软骨样组织混杂在一起。已研究表明间叶细胞和间叶成份并非真正的基质而是由肿瘤性上皮产生。骨形成蛋白(BMP)是骨基质中众多的生长因子之一,是异位骨和软骨形成的决定因子,它可诱导未分化的间充质细胞分化成软骨母细胞和骨母细胞,它有8个亚型,BMP-2～8属于转化生长因子(TGF-β)。最近发现BMP也存在于非骨组织中,BMP-2已由人肿瘤性上皮细胞系产生。本研究的目的是通过免疫细胞化学定位多形性腺瘤中的BMPs和TGF-β,从而分析BMPs在多形性腺瘤软骨成份的组织发生中的作用。
Pleomorphic adenoma is the most common salivary gland benign tumor, histological pleomorphic characteristics, that is, tumor epithelial tissue and mucoid, cartilage-like tissue mixed together. Studies have shown that mesenchyme and mesenchyme components are not real matrices but are produced by neoplastic epithelium. Bone morphogenetic protein (BMP), one of the many growth factors in bone matrix, is a determinant of ectopic bone and chondrogenesis that induces the differentiation of undifferentiated mesenchymal cells into chondroblasts and osteoblasts. It has Eight subtypes, BMP-2 ~ 8 belong to transforming growth factor (TGF-β). BMPs have also recently been found in non-bone tissue, and BMP-2 has been produced by human tumor epithelial cell lines. The purpose of this study was to characterize the role of BMPs in the histogenesis of pleomorphic adenoma cartilage components by immunocytochemically targeting BMPs and TGF-β in pleomorphic adenomas.