论文部分内容阅读
目的探讨儿童中枢神经系统(CNS)感染的免疫学检测、EEG及影像学(CT、MRI)改变之间的关系。方法采用速率散射比浊法定量检测CNS感染患儿血清和脑脊液(CSF)中清蛋白、IgG及免疫球蛋白游离轻链κ、λ水平,计算CSF和血清中清蛋白商值(QALB)、免疫球蛋白商值(QIgG)、κ游离轻链商值(Qκ)、λ游离轻链商值(Qλ);同时行EEG及CT、MRI检查。结果化脓性脑膜炎组和病毒性脑膜炎组QALB、QIgG、Qκ、Qλ均显著高于对照组(P<0.01,0.05);CNS感染患儿EEG、CT、MRI异常程度与血脑脊液屏障损伤程度呈平行关系,血脑脊液屏障损伤程度愈重,EEG、CT、MRI异常程度愈明显。结论免疫学检测、EEG及影像学综合分析可作为判断CNS感染患儿血脑脊液屏障受损及功能的辅助诊断指标之一。
Objective To investigate the relationship between immunological detection of children’s central nervous system (CNS) infection and changes of EEG and imaging (CT, MRI). Methods The serum, CSF and albumin, IgG and immunoglobulin free light chain κ and λ levels in children with CNS infection were quantitatively measured by rate nephelometry. The serum and serum albumen quotient (QALB) were calculated and immunized (QIgG), kappa free light chain (kappa) value and λ free light chain quotient (Qλ). EEG, CT and MRI were performed at the same time. Results The levels of QALB, QIgG, Qκ and Qλ in purulent meningitis group and viral meningitis group were significantly higher than those in control group (P <0.01, 0.05). The severity of EEG, CT and MRI in children with CNS infection was significantly lower than that in control group In a parallel relationship, the greater the degree of blood-brain barrier damage, EEG, CT, MRI more obvious abnormalities. Conclusion The results of immunological detection, EEG and imaging analysis can be used as a diagnostic index to judge the damage and function of blood-cerebrospinal fluid barrier in children with CNS infection.