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作者指出,对倍受关注的喹诺酮类药物的副作用须加以警惕。中枢神经系统的特有反应、黄嘌呤衍生物的体内浓度上升、日光过敏性及向骨骼成长点的集积等均可称之为新喹诺酮类药物的特征。正是由于新喹诺酮类药物药效优良,才更须对其安全性进行慎重研究。已临床使用的氟喹诺酮类药物有诺氟沙星(NFLX)、氧氟沙星(OFLX)、依诺沙星、(ENX)、环丙沙星(CPFX),此外正处于开发中的T-3262、NY-198、AM-833及AT-4140,可达10个品种。在最先开发出的NFLX的药效评价中,其对中枢神经的影响与不含氟的喹诺酮相比
The authors point out that vigilance should be paid to the side effects of quinolones that have drawn much attention. The unique response of the central nervous system, increased concentrations of xanthine derivatives in vivo, sunlight sensitivity and accumulation of bone growth point, etc. can be characterized as new quinolones. It is precisely because of the excellent efficacy of the new quinolones, it is even more necessary to conduct a careful study of its safety. Fluoroquinolones that have been used clinically are norfloxacin (NFLX), ofloxacin (OFLX), enoxacin, (ENX), ciprofloxacin (CPFX) and, in addition, are under development in the T- 3262, NY-198, AM-833 and AT-4140, up to 10 varieties. In the first development of NFLX efficacy evaluation, its impact on the central nervous and non-fluorine-containing quinolone compared