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1985年 Jeffreys 对中度重复的“小卫星DNA”限制性片段长度多态(RFLP)进行了描述,从而促进了 DNA 指纹图谱技术的发展。本文报道用 M13噬菌体探针,利用 DNA指纹图技术诊断一例表型为正常女性的 XX/XY 嵌合体。其研究表明 DNA 指纹图的应用有助于自发性的嵌合型的诊断。
In 1985, Jeffreys described the moderately repeated “small satellite DNA” restriction fragment length polymorphism (RFLP) described, thus contributing to the development of DNA fingerprinting technology. This paper reports the use of M13 phage probes to diagnose a case of XX / XY chimera of a normal female phenotype using DNA fingerprinting. Its research shows that the application of DNA fingerprinting contributes to the diagnosis of spontaneous chimerism.