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虽在1958年毛细胞白血病已被认为是具有明确的临床病理的疾病,仅近来才制订了治疗策略。回顾性分析认为切脾有益而化疗有害。但有两篇报导提到严重的病人用攻击性联合化疗是有益的。本病的临床表现是由两个脏器系统受白血病浸润所致,一是脾脏的红髓被毛细胞浸润引起脾功能亢进,一是骨髓被浸润导致增生低下和全血细胞减少。脾功能亢进多数通过切脾能得到纠正,约有27%的病人以后会有骨髓进行性疾病,其表现或为各类细胞减少的白血病相,或为全血细胞减少。本文主要讨论后者的治疗策略。有44例毛细胞白血病患者,其中26例作了脾切除,后者中19例无需进一步治疗,7例病情发展需要
Although hairy cell leukemia was thought to have a definite clinical and pathological condition in 1958, treatment strategies have only recently been developed. Retrospective analysis that the spleen beneficial and chemotherapy harmful. However, two reports mentioned that it is beneficial to use aggressive combination chemotherapy in a serious patient. The clinical manifestations of the disease is caused by two organ systems leukemia infiltration caused by one is the spleen of the red blood cells infiltration caused by hair cells hypersplenism, one is the infiltration of bone marrow lead to hyperplasia and pancytopenia. Most of hypersplenism can be corrected by splenectomy, about 27% of patients will later have bone marrow progressive disease, the performance of various types of cells or reduced leukemia, or pancytopenia. This article focuses on the latter’s treatment strategy. There were 44 cases of hairy cell leukemia patients, including 26 cases of splenectomy, the latter 19 cases without further treatment, 7 cases of disease development needs