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本文研究了三硝基甲苯对小鼠骨髓细胞染色体畸变和微核率的影响。三硝基甲苯实验组的小鼠骨髓细胞染色体畸变明显增高,且呈现剂量-反应关系,实验组小鼠骨髓嗜多染红细胞微核率明显高于对照组(P<0.001)。这些结果表明,三硝基甲苯是一种致突变物。
In this paper, the effect of trinitrotoluene on chromosome aberration and micronucleus rate of bone marrow cells in mice was studied. In the trinitrotoluene experimental group, chromosome aberration of mouse bone marrow cells was significantly increased and showed a dose-response relationship. The micronucleus rate of polychromatic erythrocytes in the experimental group was significantly higher than that of the control group (P<0.001). These results indicate that trinitrotoluene is a mutagen.