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研究通过复制犬碳酸氢钠纠正的急性代谢性酸中毒动物模型，动态观察动脉血和脑脊液（ＣＳＦ）酸碱变量。结果发现：当碳酸氢钠大剂量快速输入后，ｐＨａ虽恢复正常，而ｐＨＣＳＦ从代谢性酸中毒时的７．３５１下降到７．１９２，ＰＣＳＦＣＯ２从代谢性酸中毒时的５．３７１９ｋＰａ上升到８．５３１２ｋＰａ，ＣＳＦ发生急性呼吸性酸中毒。这可能是一些危重的代谢性酸中毒病人在使用较大剂量碳酸氢钠纠酸后出现种经精神症状的主要原因之一。
Animal models of acute metabolic acidosis corrected by the replication of dog bicarbonate were studied in order to dynamically observe the acid-base and acid-base variables of arterial blood and cerebrospinal fluid (CSF). The results showed that when pHaF returned to normal after high-dose sodium bicarbonate infusion with a high dose, and pHCSF decreased from 7.351 to 7.192 when metabolic acidosis was observed, PCSFCO2 increased from 5.3719kPa for metabolic acidosis to 8 .5312kPa, CSF acute respiratory acidosis. This may be one of the major causes of psychiatric symptoms in critically ill patients with metabolic acidosis after using larger doses of sodium bicarbonate to correct their acidosis.