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目的探讨高血压脑出血患者急性期强化降压治疗的有效性和安全性。方法 106例急性脑出血患者随机分为强化组(55例)和对照组(51例)。强化组对血压超过140~150 mmHg的患者在发病后6 h内快速降至140 mmHg以下并维持24 h,对照组按前版AHA指南降压。比较两者治疗24 h后血肿大小和第14天的神经功能缺损情况、治疗有效率。结果强化组和对照组有效率分别为87.2%和60.8%,差异有统计学意义。神经功能缺损改善情况比较,差异有统计学意义。结论脑出血后强化降压治疗,能显著改善患者预后。
Objective To investigate the efficacy and safety of intensive antihypertensive therapy in patients with hypertensive cerebral hemorrhage in acute stage. Methods One hundred and sixty patients with acute cerebral hemorrhage were randomly divided into intensive group (55 cases) and control group (51 cases). In the intensive group, the patients whose blood pressure exceeded 140-150 mmHg were rapidly reduced to below 140 mmHg within 6 h after onset and maintained for 24 h. The control group was depressurized according to the previous AHA guidelines. The hematoma size and neurological deficit on the 14th day after 24 h treatment were compared, and the treatment efficiency was compared. Results The effective rates of the intensive group and the control group were 87.2% and 60.8%, respectively, with significant differences. Compared with the improvement of neurological deficit, the difference was statistically significant. Conclusion Intensive antihypertensive treatment after intracerebral hemorrhage can significantly improve the prognosis of patients.