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Aim:To report the fine needle aspiration cytology(FNAC)of the testes used as a diagnostic tool in non-obstructiveazoospermic patients.Methods:One hundred and twenty-five non-obstructive azoospermic male candidates tointracytoplasmic sperm injetion(ICSI)were analysed for follicle stimulating hormone(FSH),luteinizing hormone(LH),testosterone and inhibin B plasma levels.They were classified into three groups on the basis of FNAC:1)Sertolicell-only syndrome(SCOS)(70);2)severe hypospermatogenesis(42);and 3)maturation arrest(13).Then,all menunderwent testicular sperm extraction(TESE)for sperm recovery for ICSI.Results:Mature spermatozoa weredetected by FNAC in 24 of 42 men with severe hypospermatogenesis and nine of 13 men with maturation arrest;while they were retrieved by TESE in 29 of 70 men with SCOS,35 of 42 men with severe hypospermatogenesis(including the 24 by FNAC)and 10 of 13 men with maturation arrest(including the nine by FNAC).The sensitivityand specificity of FNAC were 44.6 % and 100 %,respectively.There was no difference on testicular volume andhormonal parameters in men with and without sperm retrieved.Conclusion:These findings suggest that FNAC maybe a simple and valid diagnostic parameter in non-obstructive azoospermic men and it may represent a valid positiveprognostic parameter for sperm recovery at TESE.
Aim: To report the fine needle aspiration cytology (FNAC) of the testes used as a diagnostic tool in non-obstructiveazoospermic patients. Methods: One hundred and twenty-five non-obstructive azoospermic male candidates to inactivation of sperm injetion (ICSI) were analysed for follicle stimulating hormone (FSH), luteinizing hormone (LH), testosterone and inhibin B plasma levels. They were classified into three groups on the basis of FNAC: 1) Sertolicell-only syndrome (SCOS) ); 3) maturation arrest (13). Then, all menunderwent testicular sperm extraction (TESE) for sperm recovery for ICSI. Results: Mature spermatozoa weredetected by FNAC in 24 of 42 men with severe hypospermatogenesis and nine of 13 men with maturation arrest ; while they were retrieved by TESE in 29 of 70 men with SCOS, 35 of 42 men with severe hypospermatogenesis (including the 24 by FNAC) and 10 of 13 men with maturation arrest (including the nine by FNAC). sensitivity and specificity of FNAC were 44.6% a nd 100%, respectively. There was no difference on testicular volume and hormone parameters in men with and without sperm retrieved. Conclusion: These findings suggest that FNAC maybe a simple and valid diagnostic parameter in non-obstructive azoospermic men and it may represent a valid positive prognosticate parameter for sperm recovery at TESE.