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目的观察多西紫杉醇联合奥沙利铂和氟尿嘧啶治疗晚期胃癌的疗效和毒副反应。方法21例晚期胃癌患者采用多西紫杉醇联合奥沙利铂和氟尿嘧啶方案治疗,评价近期疗效和毒副反应,疾病进展时间(TTP)和中位生存期(MST)。结果21例均可评价疗效,其中完全缓解1例,部分缓解11例,稳定5例,进展4例。有效率为57.14%,中位TTP为5.8个月,MST为10.5个月。毒副反应主要是骨髓抑制,其次为胃肠道反应、口腔黏膜炎、腹泻及周围神经毒性。结论多西紫杉醇联合奥沙利铂和氟尿嘧啶方案治疗晚期胃癌的疗效较好,毒副反应可以耐受。
Objective To observe the efficacy and side effects of docetaxel combined with oxaliplatin and fluorouracil in the treatment of advanced gastric cancer. Methods Twenty-one patients with advanced gastric cancer were treated with docetaxel combined with oxaliplatin and fluorouracil. The curative effect, adverse reaction, time to progression (TTP) and median survival (MST) were evaluated. Results All the 21 patients could evaluate the curative effect, including 1 complete remission, partial remission in 11 cases, stable 5 cases and progression in 4 cases. The effective rate was 57.14%. The median TTP was 5.8 months and the MST was 10.5 months. Toxic side effects are mainly myelosuppression, followed by gastrointestinal reactions, oral mucositis, diarrhea and peripheral neurotoxicity. Conclusion Docetaxel combined with oxaliplatin and fluorouracil regimen is effective in the treatment of advanced gastric cancer, and toxicity can be tolerated.