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目的探讨前列地尔与贝那普利联合治疗对糖尿病肾病蛋白尿的影响。方法 60例2型糖尿病肾病患者随机分为观察组和对照组,每组30例。两组患者均给予降血糖等处理,观察组同时给予前列地尔与贝那普利联合治疗。检测两组患者治疗前和治疗4周后的24 h尿蛋白含量和治疗4周后的24 h尿微蛋白排泄率。结果观察组治疗前24 h尿蛋白含量和24 h尿微蛋白排泄率检测结果和对照组治疗前的检测结果比较,差异无统计学意义(P>0.05);观察组治疗4周后的24 h尿蛋白含量和24 h尿微蛋白排泄率检测结果和对照组检测结果比较,差异有统计学意义(P<0.05)。结论前列地尔与贝那普利联合治疗能够改善糖尿病肾病蛋白尿状况,效果显著,值得借鉴。
Objective To investigate the effect of combination therapy of alprostadil and benazepril on diabetic nephropathy proteinuria. Methods Sixty patients with type 2 diabetic nephropathy were randomly divided into observation group and control group, 30 cases in each group. Both groups were given hypoglycemic treatment, the observation group were given both alprostadil and benazepril combined treatment. The 24-hour urinary protein levels before and after 4 weeks of treatment and the 24-hour urinary protein excretion rate after 4 weeks of treatment were measured in both groups. Results There was no significant difference in urinary protein level and urinary protein excretion rate at 24 hours before treatment between the observation group and the control group before treatment (P> 0.05). After 24 hours Urine protein content and 24 h urine micro-protein excretion rate test results compared with the control group, the difference was statistically significant (P <0.05). Conclusions The combination of alprostadil and benazepril can improve the proteinuria of diabetic nephropathy. The results are significant and worth learning from.