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目的观察芪苈强心胶囊辅治慢性心力衰竭(CHF)伴肾功能不全的疗效。方法选择CHF伴有肾功能不全(血肌酐177～443μmol/L)患者120例随机分为2组:治疗组(n=60)为芪苈强心胶囊加常规CHF治疗;对照组(n=60)为常规CHF治疗,疗程均12周。治疗结束后观察比较2组患者心功能改善情况及不良反应发生情况。结果治疗后2组患者心功能分级均较治疗前得到改善,左室射血分数(LVEF)及心输出量(CO)均提高,左室舒张末内径(LVEDD)缩小(P均<0.05),且治疗组心功能分级改善及LVEF、CO提高均优于对照组(P<0.05),而LVEDD差异无统计学意义(P>0.05)。治疗组地高辛中毒发生率低于对照组(P<0.05)。结论芪苈强心胶囊辅治可明显改善CHF伴肾功能不全的患者心功能,减少地高辛中毒的发生率,提高疗效。
Objective To observe the effect of Qili Qiangxin Capsule in treating chronic heart failure (CHF) with renal insufficiency. Methods 120 cases of CHF with renal insufficiency (serum creatinine 177 ~ 443μmol / L) were randomly divided into two groups: the treatment group (n = 60) was treated with Qiliqiangxin capsule plus conventional CHF; the control group (n = 60 ) For conventional CHF treatment, treatment were 12 weeks. After treatment, the improvement of cardiac function and the occurrence of adverse reactions in the two groups were observed and compared. Results After treatment, the heart function scores of two groups were improved, LVEF and CO increased, and LVEDD decreased (P <0.05) The improvement of cardiac function and the improvement of LVEF and CO in the treatment group were better than those in the control group (P <0.05), while there was no significant difference in LVEDD between the two groups (P> 0.05). The incidence of digoxin poisoning in the treatment group was lower than that in the control group (P <0.05). Conclusion Qiliqiangxin capsule can significantly improve heart function in CHF patients with renal insufficiency, reduce the incidence of digoxin poisoning and improve the curative effect.