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目的 观察米索前列醇产后阴道置药预防产后出血的疗效。方法 选择 51 2例住院分娩者随机分为 3组 :米索前列醇组、催产素组及米索前列醇 +催产素组 (合用组 )。米索前列醇组 82例在分娩后 40min内处理完伤口后于阴道后穹窿置药米索前列醇40 0 μg ,催产素组 2 2 7例在分娩后立即肌内注射催产素 2 0U ,合用组 2 0 3例则同时应用米索前列醇和催产素 ,用药方法分别与米索前列醇组和催产素组相同。 3组均用容积法及面积法观察产后 2h内及产后 2 4h内出血量。结果 米索前列醇组与合用组的产后出血量均少于催产素组 ,差异有显著性 (P <0 .0 0 1 ) ,但米索前列醇组与合用组的产后出血量的差异无显著性 (P >0 .0 5) ,且催产素组发生产后出血 4例 ,而米索前列醇组与合用组均未发生产后出血。结论 米索前列醇加强宫缩的效果比催产素好 ,产后阴道用药能有效地减少产后出血量
Objective To observe the effect of misoprostol vaginal delivery to prevent postpartum hemorrhage. Methods Fifty-two cases of hospital delivery were randomly divided into 3 groups: misoprostol group, oxytocin group and misoprostol + oxytocin group (combined group). In the misoprostol group, 82 cases were treated with 40 0 μg misoprostol in the posterior vaginal fornix within 40 minutes after delivery, and 227 cases in the oxytocin group were intramuscularly injected with 20 U of oxytocin immediately after delivery Group 2 0 3 cases of both misoprostol and oxytocin, medication method and misoprostol group and oxytocin group. 3 groups were volume method and area method to observe the amount of bleeding within 2h postpartum and within 24 hours after delivery. Results The amount of postpartum hemorrhage in misoprostol group and combined group was less than that in oxytocin group (P <0.01), but there was no significant difference in postpartum hemorrhage between misoprostol group and combination group (P> 0.05). There were 4 cases of postpartum hemorrhage in the oxytocin group, and no postpartum hemorrhage occurred in the misoprostol group and the combination group. Conclusion The effect of misoprostol on contractions is better than that of oxytocin. Postpartum vaginal administration can effectively reduce the amount of postpartum hemorrhage