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大剂量用药、多药合并用药以及长期用药倾向的发展,使药物诱发疾病有显著上升趋势。作者统计国内1977～1981年32种期刊汇集3459例,年平均692例(死亡293人)。仅略低于日本。在此基础上,作者从病理学角度分析了药物诱发疾病的动向,指出今后除药物性休克及过量中毒外,应加强对肝、肾、肺等重症内脏型病变及药物性自体免疫疾病的报道与探讨。并简略地介绍了此类疾病的临床特点与病理性质,以期引起临床药学工作者的密切注意。
Large doses of medication, multi-drug combination and the long-term medication development, the drug-induced diseases have a significant upward trend. Authors Statistics 3459 cases were collected from 32 kinds of journals in China in 1977 ~ 1981, with an average annual number of 692 (293 deaths). Only slightly lower than Japan. On this basis, the author analyzed the trend of drug-induced diseases from the pathological point of view, pointed out that in addition to drug shock and excessive poisoning, should strengthen the liver, kidney, lung and other severe visceral lesions and drug-induced autoimmune diseases And explore. And briefly introduced the clinical features and pathological nature of these diseases, with a view to arouse the close attention of clinical pharmacy workers.