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【目的】观察左氧氟沙星联合标准化疗方案治疗肺结核的疗效及对患者血清γ干扰素(INF-γ)、白细胞介素10(IL-10)含量的影响。【方法】将60例肺结核患者随机分为观察组和对照组各30例；对照组给予标准化疗方案治疗,观察组在对照组的基础上联合左氧氟沙星治疗；观察比较两组患者在治疗2、4、6个月后的痰菌阴转率和病灶吸收情况,ELISA 法检测血清中 INF-γ、IL-10的含量变化,并观察治疗期间的用药安全性。【结果】观察组治疗2个月、6个月的痰菌阴转率及治疗6个月后的病灶明显吸收率分别为56.67%、93.33%和63.33%,均明显高于对照组的33.33%、70.00%和43.33%,差异有统计学意义(P <0.05)；用药2、4、6个月后两组血清 INF-γ含量增加、IL-10含量减少,与治疗前比较差异均有统计学意义(P <0.05),且观察组血清 INF-γ水平在治疗2、4个月后和 IL-10水平在治疗2个月后的改善情况均较对照组更明显(P 0.05)。【结论】左氧氟沙星联合标准化疗方案治疗肺结核疗效显著,其治疗作用可能与调节外周血中 INF-γ、IL-10的含量有关。“,”Objective]To explore the efficacies of levofloxacin plus standard chemotherapy in the treat-ment of tuberculosis and observe the serum levels of interferon-gamma (INF-γ)and interleukin-10 (IL-10).[Methods]A total of 60 cases of pulmonary tuberculosis were randomly divided into observation and control groups (n=30 each).The control group received standard chemotherapy while observation group had an addi-tion of levofloxacin.Two groups were compared at Months 2,4 and 6 after sputum conversion and focal ab-sorption.The serum contents of INF-γand IL-10 were detected by enzyme-linked immunosorbent assay (ELISA).And drug safety was observed during treatment.[Results]The sputum conversion rates at Months 2,6 and lesion absorption rate at Month 6 were 56.67%,93.33% and 63.33% respectively and they were sig-nificantly higher than 33.33%,70.00% and 43.33% in control group respectively.And the differences were statistically significant (P < 0.05 ).At Months 2,4 and 6,serum INF-γincreased while serum IL-10 de-creased versus pre-treatment.And the differences were statistically significant (P <0.05 or P <0.01).In ob-servation group,serum INF-γat Months 2,4 and serum IL-10 at Month 2 improved more obviously than those in control group (P <0.05 or P 0.05).[Conclusion]The combined regimen of levofloxacin plus standard chemotherapy is sig-nificantly efficacious in the treatment of pulmonary tuberculosis.And the mechanism may be due to a regula-tion of INF-γand IL-10 in peripheral blood.