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商陆皂甙甲（ＥｓＡ）体外在０．０１～１０μｍｏｌ·Ｌ－１范围内，对小鼠腹腔巨噬细胞吞噬中性红和ＬＰＳ诱导的巨噬细胞合成及释放白介素１都呈明显的抑制作用。体内给药２．５～５ｍｇ·ｋｇ－１可显著减少绵羊红细胞致敏的小鼠血清溶血素的含量。提示ＥｓＡ的抗炎作用可能主要通过抑制巨噬细胞的吞噬和分泌功能。ＥｓＡ间接作用于Ｂ细胞，抑制抗体生成。
Phylloside A (EsA) in the range of 0.01 to 10 μmol·L-1 in vitro inhibits phagocytic necrosis of mouse peritoneal macrophages and macrophages synthesis induced by LPS and release of interleukin-1 . Administration of 2.5 to 5 mg·kg-1 in vivo significantly reduced serum hemolysin levels in sheep sensitized mice. It suggests that the anti-inflammatory effect of EsA may be mainly by inhibiting the phagocytic and secretory functions of macrophages. EsA indirectly acts on B cells and inhibits antibody production.