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目的:通过实验观察电针“足三里”对雷公藤甲素所致大鼠急性肝损伤的影响.方法:将SD大鼠随机分为空白组、电针组和药物组,经电针“足三里”预处理14天后,建立雷公藤甲素急性肝损伤大鼠模型,观察三组大鼠肝组织匀浆ALT、AST、SOD、MDA、TNF-α、NO、IL-10的含量.结果:电针组AST、ALT、MDA、TNF-α、NO指标值均比对照组低,SOD、IL-10指标值比对照组高.结论:电针预处理可以减轻雷公藤甲素对肝组织的损伤,其机理与抑制靶器官损伤相关的因子释放,提高机体抗氧化应激的能力有关.“,”Objective:To investigate the effects of electro-acupuncture pretreatment of Tsusanli on acute hepatic injury caused by Triptolide in rats.Methods:SD rats were randomly divided into blank controlled group,electro-acupuncture group and drug controlled group.Establishing the acute hepatic injury rat model by feeding the rats with Triptolide,after electro-acupuncture pretreatment at “Tsusanli”.Detecting the content of ALT,AST,SOD,MDA,TNF-α,NO,IL-10in rat liver homogenate.Results:The level of AST,ALT,MDA,TNF-α,NO,of the electro-acupuncture group were lower than those of the controlled group,While the level of SOD,IL-10of the electro-acupuncture group were higher than those of the controlled group.Conclusion:Electro-acupuncture pretreatment can in a certain reduce the effects of Triptolide on liver tissue injury,the mechanism is possibly related to inhibiting the release of target organ damage factors,and enhance the ability of antioxidants.