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目的 观察在给S-180小鼠5-FU腹腔注射同时灌胃采用不同剂量CF能否增强5-FU抗小鼠S-180作用和对5-FU引起白细胞、血小板下降的影响;以及两药联合应用时对人胃癌细胞MGC的体外抑制增效作用。方法 给S-180小鼠腹腔注射5-FU25～15mg/(kg·d),连续用5天、7天,并在用5-FU前半小时灌胃CF60、90或120mg/(kg·d)。结果 各5-FU单用组抑制率为42.3%～44.5%;若合用组CF剂量≥90mg/(kg·d),抑瘤率可提高至59.4%～73.3%(差异有显著性);体外实验显示作用96小时后,各浓度CF/5-FU合用组抑瘤率均明显高于5-FU单用组;毒性试验显示CF/5-FU合用组对白细胞、血小板的影响与5-FU单用组差异无显著性。结论 若用5-FU前灌胃CF90或120mg/(kg·d)则可明显增加5-FU的抑瘤效应;CF可明显增强5-FU对MGC的增殖抑制作用,但合用时两者剂量均不必过高,时间需96小时以上;CF对5-FU的骨髓抑制作用基本没有影响。
Objective To observe the effects of intraperitoneal injection of 5-FU in S-180 mice and intragastric administration of different doses of CF on the effects of 5-FU anti-mouse S-180 and on 5-FU-induced leukocyte and platelet decline; Combined application of human gastric cancer cell MGC in vitro inhibition and synergy. Methods S-180 mice were injected intraperitoneally with 5-FU 25-15 mg/(kg·d) for 5 days and 7 days, and CF60, 90 or 120 mg/(kg·d) was administrated half an hour before 5-FU. . Results The inhibition rate of 5-FU single-use group was 42.3%-44.5%; if the combined dose of CF was ≥90mg/(kg·d), the tumor inhibition rate could be increased to 59.4%-73.3% (significant difference); The experiment showed that after 96 hours of action, the inhibition rate of each concentration of CF/5-FU combination group was significantly higher than that of 5-FU alone group; Toxicity test showed that the combination of CF/5-FU on white blood cells, platelets and 5-FU There was no significant difference in the single-use group. Conclusion If 5-FU is used to administer CF90 or 120 mg/(kg·d), the anti-tumor effect of 5-FU can be significantly increased; CF can significantly enhance the inhibitory effect of 5-FU on the proliferation of MGC, but both doses are combined. Do not need to be too high, the time required more than 96 hours; CF on the 5-FU myelosuppression basically no effect.