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目的 通过检测注意缺陷障碍(ADHD)儿童血中兴奋/抑制性氨基酸代谢水平,探求它们与ADHD的关系及与心理行为的相关性。方法 采用反向高效液相色谱法,测定2 0 0 3年8月在上海第二军医大学附属长征医院随机抽取的5 8例注意缺陷障碍儿童(ADHD组:其中注意缺陷为主型2 2例;多动 冲动为主型4例;混合型32例)和30例健康对照儿童血清兴奋性氨基酸中的谷氨酸(Glu)、天冬氨酸(Asp)和抑制性氨基酸甘氨酸(Gly)的浓度并进行比较。结果 (1)ADHD组儿童血清兴奋性氨基酸Glu、Asp浓度分别为(16 9. 13±2 6 . 6 2 ) μmol/L和(2 9 .19±2 . 5 6 ) μmol/L ,显著低于对照组(P <0 .0 1) ,而抑制性氨基酸Gly浓度为(489. 78±96 . 2 6 ) μmol/L ,显著高于对照组(P <0 .0 5 )。(2 )不同类型ADHD儿童之间血清兴奋性和抑制性氨基酸浓度未见有统计学意义上的差异。(3)兴奋性和抑制性氨基酸浓度和DSM Ⅳ父母版所得各项分数之间无相关性。结论 ADHD儿童血清中存在兴奋/抑制性氨基酸的失调,此种失调可能参与了ADHD的病理生理过程。
Objective To investigate the relationship between the level of excitatory / inhibitory amino acid metabolism in children with attention deficit disorder (ADHD) and their relationship with ADHD and their psychological behavior. Methods Reverse-phase high performance liquid chromatography (RP-HPLC) was used to detect 58 randomly selected children with attention-deficit disorder who were randomly selected from the Changzheng Hospital affiliated to Shanghai Second Military Medical University in August 2003 (ADHD group: 22 with predominant type of attention deficit ; Hyperactivity-impulsive predominant type (4 cases); mixed type (32 cases)) and 30 healthy children with serum excitatory amino acids of glutamic acid, aspartic acid and inhibitory amino acid glycine Concentration and compare. Results (1) The concentrations of serum excitatory amino acids Glu and Asp in children with ADHD were (16.913 ± 26.62) μmol / L and (29.19 ± 2.56) μmol / L, respectively, which were significantly lower (P <0.01), while the inhibitory amino acid Gly concentration was (489. 78 ± 96.26) μmol / L, which was significantly higher than that of the control group (P <0.05). (2) There was no statistically significant difference between serum excitability and inhibitory amino acid concentration in children with different types of ADHD. (3) There was no correlation between excitatory and inhibitory amino acid concentrations and scores obtained from the parental version of DSM IV. Conclusion There is an imbalance of excitatory / inhibitory amino acids in serum of children with ADHD, which may be involved in the pathophysiological process of ADHD.