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接受作者研究的均为1980～1984年间经拉各斯大学教学医院血红蛋白电泳证实的镰状红细胞贫血病人,均有频发疼痛危象和反复咽痛的病史。经全面的耳鼻咽喉检查,除去患慢性咽炎和鼻蜜炎的病人,发现同时患有慢性扁桃体炎者15名。其中9名女性,8名男性,年龄为6～35岁,平均15岁。病人在全麻下切除扁桃体,术后一年内发生疼痛危象的次数从术前每年平均4.7次降为1.5次,有显著的统计学意义(P<0.001)。作者认为,疼痛危象发作次数在术后减少的原因是手术防止了进一步急性发热性感染的发怍。Barrett-Connor(1971)也间接证明了感染可诱发镰状细胞危象,Warley等(1965)观察了一组患镰状红细胞贫血的儿童在接受氯喹和青霉素化学预防后痛性指(趾)炎发作率显著减低及血红蛋白平均浓度增高。作者认为本文结果提供了扁桃体感染是镰状细胞疼痛危象原因的有力证据。特别是在
All the authors studied were sickle cell anemia patients confirmed by hemoglobin electrophoresis at Lagos University Teaching Hospital between 1980 and 1984, and all had a history of frequent pain crisis and repeated sore throat. After a comprehensive otolaryngology check to remove patients with chronic pharyngitis and nasal inflammation, 15 were found to suffer from chronic tonsillitis at the same time. Among them, nine women and eight men, aged 6 to 35 years old, average 15 years old. The patient underwent tonsillectomy under general anesthesia. The number of painful crises within one year after surgery was reduced from 4.7 to 1.5 times per year, with significant statistical significance (P <0.001). The authors argue that the reason for the reduction in the number of painful crises after surgery is that surgery prevented the development of further acute febrile infections. Barrett-Connor (1971) also indirectly demonstrated that infection can induce sickle cell crisis. Warley et al. (1965) looked at a group of children with sickle cell anemia who received chemotherapy with chloroquine and penicillin for painful toe inflammation Seizure rate was significantly reduced and the average hemoglobin concentration increased. The authors concluded that the results presented here provide strong evidence that tonsil infection is the cause of sickle cell pain crisis. especially in