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在过去10年,抗乙型肝炎病毒(HBV)治疗药物种类和数量剧增,对HBV感染的自然史影响较大。但至今,慢性HBV感染仍然是肝硬化和肝癌发生的重要原因。慢性乙型肝炎(CHB)为一动态过程,其自然史可概括为5个期:免疫耐受期、活动期、非活动HBV携带期、HBeAg阴性CHB、HBsAg阴性期,但这5个期不一定连续出现。认识慢性HBV感染后的动态自然史,对慢性HBV感染者的处理、适时治疗方案的选择、早期预防和监测均具有重要意义。
In the past 10 years, anti-hepatitis B virus (HBV) treatment of drug types and the number of surge in the natural history of HBV infection have a greater impact. But so far, chronic HBV infection is still an important cause of cirrhosis and liver cancer. Chronic hepatitis B (CHB) is a dynamic process. Its natural history can be summarized as five phases: immune tolerance period, active phase, inactive HBV carrier phase, HBeAg negative CHB, HBsAg negative phase, but these five phases are not Must appear continuously. Understanding the natural history of chronic HBV infection after dynamic, chronic HBV infection treatment, timely treatment options, early prevention and monitoring are of great significance.