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外科切除被认为是肝细胞癌(hepatocellular carcinoma,下文简称肝癌)的主要治疗手段,但合并肝功能严重不全的肝癌患者往往无法耐受外科手术切除。约80%肝癌患者存在肝硬变背景,外科切除无法阻止肝癌患者剩余肝脏的癌变过程及肝硬变的进一步发展。这也是导致外科切除术后远期死亡的病因,即肿瘤复发和慢性肝功能衰竭。[1-2]
Surgical resection is considered as the primary treatment for hepatocellular carcinoma (HCC), but patients with HCC who have severe liver dysfunction often can not tolerate surgical resection. About 80% of liver cancer patients with liver cirrhosis background, surgical resection can not prevent the liver cancer patients remaining liver cancer process and further development of cirrhosis. This is also the cause of long-term mortality after surgical resection, namely tumor recurrence and chronic liver failure. [1-2]