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目的:研究分析干扰素对婴幼儿轮状病毒性肠炎的治疗效果,为其临床应用提供相应的数据支撑。方法:随机选取我院2012年1月-2013年12月期间住院病人,入选对象选自于我科收治的212例确诊为轮状病毒性肠炎患儿,根据患儿入院治疗的时间以及治疗期间所接受的不同治疗方案,将212例患儿随机分为两组:对照组患儿103例,住院期间给予对症支持、补液、纠正电解质紊乱、酸碱失衡等常规治疗,观察组患儿109例,住院期间在上述常规治疗的基础上加用干扰素治疗。比较两组患儿的治疗效果,并采用统计学方法进行比较分析。结果:经临床治疗观察可见,观察组患儿的临床有效率为91.6%,明显优于对照组(85.0%),两组比较差异具有明显统计学意义(P<0.05);观察组患儿的腹泻好转时间为(4.16±1.03)d,对照组患儿的腹泻好转时间为(5.41±1.042)d,观察组短于对照组(P<0.05);经3 d的治疗后,观察组患儿的转阴率(90.8%)明显高于对照组(70.9%),组间比较差异存在统计学意义(P<0.05)。结论:采用干扰素治疗轮状病毒性肠炎患儿能够有效的改善患儿的症状,提高治疗效果,值得临床推广应用。
Objective: To study the effect of interferon on infantile rotavirus enteritis and provide corresponding data support for its clinical application. Methods: Inpatients were randomly selected from January 2012 to December 2013 in our hospital. The subjects were selected from 212 children diagnosed as rotavirus enteritis in our department. According to the time of hospital admission and the treatment period 212 cases were randomly divided into two groups: control group of 103 children, symptomatic support during hospitalization, rehydration, electrolyte imbalance correction, acid-base imbalance and other conventional treatment, the observation group of 109 patients , During the hospital based on the above conventional treatment plus interferon treatment. The therapeutic effects of the two groups were compared and statistically analyzed. Results: Clinical observation showed that the clinical effective rate in the observation group was 91.6%, which was significantly better than that in the control group (85.0%). The difference between the two groups was statistically significant (P <0.05) The improvement time of diarrhea was (4.16 ± 1.03) d, the improvement time of diarrhea in control group was (5.41 ± 1.042) d, the observation group was shorter than the control group (P <0.05); after 3 days of treatment, (90.8%) was significantly higher than that of the control group (70.9%). The difference between the two groups was statistically significant (P <0.05). Conclusion: Interferon treatment of children with rotavirus enteritis can effectively improve the symptoms of children and improve the therapeutic effect, it is worthy of clinical promotion and application.