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目的探讨立体定向术(MIQ)联合化疗治疗PCNSL的效果分析。方法本次研究随机选取了2013年4月至2015年8月我院收治的50例明确病理后的PCNSL患者,随机分为数目相等的研究组和对照组,所有患者都采用立体定向术进行治疗,研究组加用大剂量甲氨蝶呤+替莫唑胺胶囊以及化疗,最后比较两组患者的治疗效果。结果研究组患者在进行立体定向术后给予化疗,1~3周临床症状明显缓解,近期缓解率为100%,25例患者通过治疗后近期疗效完全缓解22例(88%),部分缓解3例(12%)Karnofsky评分迅速由术前的50%上升为术后的80%,对照组完全缓解20例(80%),部分缓解2例(8%),近期缓解率为88%。研究组局控率以及生存率都明显高于对照组,肿瘤复发情况也较对照组好,数据差异具有统计学意义(P<0.05)。结论立体定向术联合化疗治疗PCNSL具有一定的疗效以及安全性,有利于提高患者的生存率和改善预后降低复发率,立体定向术联合化疗也是临床治疗PCNSL的综合治疗方案之一,临床可进一步研究。
Objective To investigate the effect of stereotactic (MIQ) combined with chemotherapy on PCNSL. Methods Fifty patients with PCNSL who were admitted to our hospital from April 2013 to August 2015 were randomly selected and randomly divided into study group and control group with equal numbers. All patients were treated with stereotactic technique , The study group plus high-dose methotrexate + temozolomide capsules and chemotherapy, and finally compared the treatment effect of two groups of patients. Results The patients in the study group were given chemotherapy after stereotactic surgery. The clinical symptoms were relieved in 1-3 weeks, and the recent remission rate was 100%. Twenty-five patients (88%) were treated with short-term curative effect and partial response was relieved in 3 patients (12%) Karnofsky score increased rapidly from 50% preoperatively to 80% postoperatively, 20 cases (80%) completely relieved in control group and 2 cases (8%) partially relieved. The recent remission rate was 88%. The control rate and survival rate in the study group were significantly higher than those in the control group. The tumor recurrence was also better than that in the control group. The difference was statistically significant (P <0.05). Conclusion Stereotaxy combined with chemotherapy in the treatment of PCNSL has certain curative effect and safety, which is beneficial to improve the survival rate of patients and improve prognosis and reduce the recurrence rate. Stereotactic combined with chemotherapy is also one of the comprehensive treatment programs for clinical treatment of PCNSL, which can be further studied clinically .