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目的探讨对超过预产期产妇应用米索前列醇引产对新生儿血清总胆红素的影响。方法选择2010年12月至2012年12月在沈阳市沈河区妇幼保健所出生的因超过预产期引产的新生儿155例,其中无药物引产(A组)50例,催产素引产(B组)52例,米索前列醇引产(C组)53例,测定3组新生儿出生后24 h、96 h微量血清总胆红素。结果 3组新生儿出生后24 h、96 h微量血清总胆红素水平分别为:A组(47.3±1.8)umol/L、(173.9±5.9)umol/L,B组(55.8±2.1)umol/L、(198.9±6.1)umol/L,C组(64.2±2.7)umol/L、(230.9±6.1)umol/L。新生儿微量血清总胆红素水平A组低于B组、C组(P<0.05);A组、B组新生儿高胆红素血症发生率、新生儿窒息发生率低于C组(P<0.05)。结论米索前列醇用于引产可导致新生儿血清胆红素升高。
Objective To explore the effect of misoprostol induction of labor on serum total bilirubin in newborns beyond the expected date of delivery. Methods From December 2010 to December 2012, 155 newborns who were born in MCH in Shenyang were investigated. Among them, there were 155 newborns with induction of labor within the expected period, including 50 cases of induced abortion (group A), 52 cases of induced abortion (group B) , Misoprostol induction of labor (C group) 53 cases, determination of three groups of newborn after birth 24 h, 96 h trace serum total bilirubin. Results The levels of total serum bilirubin in 24 hours and 96 hours after birth in the three groups were 47.3 ± 1.8 and 173.9 ± 5.9 umol / L in group A, 55.8 ± 2.1 and umol / / L, (198.9 ± 6.1) umol / L, C (64.2 ± 2.7) umol / L, (230.9 ± 6.1) umol / L. Neonatal trace serum total bilirubin level in group A was lower than that in group B and group C (P <0.05); The incidence of neonatal hyperbilirubinemia and neonatal asphyxia in group A and group B was lower than that in group C P <0.05). Conclusion Misoprostol for induction of labor can lead to elevated serum bilirubin in newborns.