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目的对小剂量米非司酮（25mg）合并小剂量氯甲蝶呤（5mg）用于紧急避孕进行初步的临床观察。方法17名受试者在无防护性交或避孕失败后采用本方案紧急避孕。结果无论是性交后72h之内还是性交后起过72h服药，无一例妊娠，且无明显到反应发生，使小剂量来非司酮紧急避孕的效果得到了提高并且拓宽了其使用时限。结论该法有可能成为一种安全高效，不受性交时间、次数制约的新型紧急避孕方法。
Objective To investigate the preliminary clinical observation of low dose of mifepristone (25mg) combined with low dose of methotrexate (5mg) for emergency contraception. Methods Twenty-seven subjects underwent unprotected intercourse or contraception after emergency contraception. Results either within 72h after sexual intercourse or 72h after intercourse took medication, no case of pregnancy, and no significant reaction to the small dose of amphetamines emergency contraception has been improved and broadened its use of time. Conclusion The method may become a safe and efficient, free from sexual intercourse, the number of constraints of the new emergency contraception.