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目的探讨白细胞介素2(IL-2)及可溶性白细胞介素2受体(sIL-2R)与β-内酰胺类药物过敏之间的关系。方法采用ELISA检测70例β-内酰胺类药物过敏反应患者(A组)与20例正常人(B组)外周血血清IL-2及sIL-2R的水平。采用放射免疫吸附(RAST)方法检测过敏患者血清中特异性IgE抗体。结果 A组血清IL-2水平显著高于B组(P<0.05)(4.110ng/mlvs.2.070ng/ml)。A组中IgE抗体阳性患者sIL-2R水平高于抗体阴性者(3.300ng/mlvs.2.345ng/ml)(P<0.05)。结论β-内酰胺类抗生素过敏反应的发生中,外周血血清IL-2水平升高;特异性IgE抗体阳性的过敏反应与sIL-2R水平升高有关。
Objective To investigate the relationship between interleukin 2 (IL-2) and soluble interleukin 2 receptor (sIL-2R) and β-lactam allergy. Methods Serum levels of IL-2 and sIL-2R in 70 patients with β-lactam allergy (A group) and 20 normal subjects (B group) were detected by ELISA. Serum specific IgE antibodies in allergic patients were detected by radioimmunoassay (RAST). Results The level of serum IL-2 in group A was significantly higher than that in group B (P <0.05) (4.110 ng / ml vs 2.070 ng / ml). The level of sIL-2R in IgE antibody-positive patients in group A was higher than that in antibody-negative patients (3.300ng / ml vs.2.345ng / ml) (P <0.05). Conclusion The level of serum IL-2 in peripheral blood increased during the occurrence of β-lactam antibiotic allergy. The specific IgE antibody-positive allergic reaction was associated with the increased sIL-2R level.