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目的分析延边地区女性乳腺癌组织中,免疫组化指标CerbB-2、ER、PR的表达及其临床病理指标状况,为早期预防和诊治乳腺癌提供科学依据。方法对延边地区653例女性乳腺癌的有关资料进行统计分析。结果乳腺癌组织免疫组化的阳性表达分别为CerbB-2:43.7%;ER:55.6%;PR:54.4%,与某些群体存在着明显的差异(P<0.05);67.8%的患者位于41～60岁;淋巴结转移与肿瘤大小、病理分期成正比(P<0.05);CerbB-2与ER、PR的表达均呈负相关(P<0.05)。结论 653例患者CerbB-2、ER和PR的表达及其临床病理指标状况,既与有关报道相符,又具自己独立的特点。常规检测这些指标,具有较重要的临床意义和实用价值。
Objective To analyze the expression of CerbB-2, ER, PR and their clinicopathological parameters in breast cancer in Yanbian area, and provide a scientific basis for early prevention and diagnosis of breast cancer. Methods 653 cases of breast cancer in Yanbian area were statistically analyzed. Results The positive rates of immunohistochemistry in breast cancer tissues were 43.7% for CerbB-2, 55.6% for ER, 54.4% for PR, and there was a significant difference (P <0.05) between the two groups. 67.8% ~ 60 years old. The lymph node metastasis was positively correlated with tumor size and pathological stage (P <0.05). The expression of CerbB-2 was negatively correlated with ER and PR (P <0.05). Conclusion The expression of CerbB-2, ER and PR in 653 patients and their clinicopathological parameters are not only consistent with the reports but also have their own independent characteristics. Routine detection of these indicators, with more important clinical significance and practical value.