论文部分内容阅读
目的研究经皮冠状动脉介入术(PCI)和冠状动脉造影术患者造影剂肾病(CIN)的危险因素。方法选择2008年10月～2009年3月在齐鲁医院接受冠状动脉造影术和/或PCI的200例患者,分别监测造影前3d内(任意1d)和造影后第3、7天的血清肌酐(Scr)、尿素氮(BUN)和尿β2微球蛋白(β2-MG),分析冠状动脉诊疗术患者CIN的危险因素。结果200例患者中,有14例(7%)发生CIN。在CIN组和非CIN组,原有肾功能不全、糖尿病、高血压患者的比例,两组间比较,差异有统计学意义(P<0.05)。年龄、身体质量指数(BMI)、血管紧张素转换酶抑制药(ACEIs)、冠状动脉粥样硬化、造影剂剂量和高脂血症,两组间差异无统计学意义(P>0.05)。logistic多因素逐步回归分析显示原有肾功能不全和糖尿病是CIN的独立危险因素。结论高血压是CIN的一个相关危险因素;年龄、BMI、ACEIs、冠状动脉粥样硬化、造影剂剂量和高脂血症等不是CIN的相关危险因素;原有肾功能不全和糖尿病是CIN的独立危险因素。
Objective To study the risk factors of contrast-induced nephropathy (CIN) in patients undergoing percutaneous coronary intervention (PCI) and coronary angiography. Methods 200 patients undergoing coronary angiography and / or PCI at Qilu Hospital from October 2008 to March 2009 were enrolled in this study. Serum creatinine Scr, BUN and β2-MG, and to analyze the risk factors of CIN in patients undergoing coronary artery surgery. Results Of 200 patients, 14 (7%) developed CIN. In the CIN group and the non-CIN group, the proportion of patients with original renal insufficiency, diabetes and hypertension was significantly different between the two groups (P <0.05). Age, body mass index (BMI), angiotensin converting enzyme inhibitors (ACEIs), coronary atherosclerosis, contrast agent dosage and hyperlipidemia were not significantly different between the two groups (P> 0.05). Logistic multivariate stepwise regression analysis showed that the original renal insufficiency and diabetes were independent risk factors for CIN. Conclusions Hypertension is a related risk factor of CIN. Age, BMI, ACEIs, coronary atherosclerosis, contrast agent dosage and hyperlipidemia are not risk factors of CIN. The original renal insufficiency and diabetes mellitus are independent of CIN Risk factors.