论文部分内容阅读
微小RNA(miRNAs或microRNAs)是一类长20~25个核苷酸的非编码内源性单链小RNA分子,通过与靶标信使RNA的3′端非翻译区结合,抑制其翻译或直接使其降解,对基因的表达起转录后的调控作用,进而调节细胞的增殖、分化和凋亡等。研究表明,部分微小RNA在恶性肿瘤的发生发展中起重要作用。因此,研究微小RNA为揭示恶性肿瘤发病机制提供新思路,为恶性肿瘤的诊断和治疗提供新策略。
MicroRNAs (miRNAs or microRNAs) are a class of small non-coding endogenous single-stranded small RNA molecules 20 to 25 nucleotides in length that, by binding to the 3 ’untranslated region of a target messenger RNA, inhibit their translation or directly Its degradation, the gene expression after transcriptional regulation, thereby regulating cell proliferation, differentiation and apoptosis. Studies have shown that some microRNAs play an important role in the development of malignant tumors. Therefore, the study of microRNAs to reveal the pathogenesis of malignant tumors provide new ideas for the diagnosis and treatment of malignant tumors provide a new strategy.