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目的研究高尔基体蛋白73(GP73)在胃癌组织中的表达变化,初步探讨高尔基体蛋白73与胃癌发病的关系。方法随机选取2012年1月~2013年8月在哈尔滨医科大学附属第一医院病理科存档并经病理科证实的胃癌标本及癌旁组织标本,共收集癌旁正常组织30例,胃癌标本71例,用免疫组织化学法(SP法)对其进行染色,以检测高尔基体蛋白73的表达情况。结果 1GP73蛋白表达定位于细胞质,在癌旁组织及癌组织表达差异有统计学意义。2胃癌中GP73蛋白的表达水平与胃癌的TNM分期、淋巴结转移相关,差异有统计学意义(P<0.05)。结论 GP73在区别胃癌的恶性程度中起着重要的作用。胃癌组织中GP73蛋白在浸润深度、淋巴结转移、TNM分期中的差异性表达提示其可能与胃癌组织的侵袭、转移相关。
Objective To investigate the expression of GP73 in gastric cancer and to explore the relationship between Golgi 73 and gastric cancer. Methods From January 2012 to August 2013, 30 gastric cancer specimens and adjacent non-cancerous tissue specimens, which were archived and pathologically confirmed, were collected from the First Affiliated Hospital of Harbin Medical University. Totally 71 cases of gastric cancer specimens were collected, , Stained with immunohistochemistry (SP method) to detect the expression of Golgi protein 73. Results The expression of 1GP73 protein localized in the cytoplasm, and there was significant difference in the expression of paracancer tissues and cancer tissues. The expression of GP73 protein in gastric cancer was correlated with TNM stage and lymph node metastasis of gastric cancer (P <0.05). Conclusion GP73 plays an important role in differentiating the malignant degree of gastric cancer. The differential expression of GP73 in gastric cancer tissues in depth of invasion, lymph node metastasis and TNM staging suggests that GP73 may be involved in the invasion and metastasis of gastric cancer.