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采用间接免疫荧光技术,检测了采自安徽大别山区某县310份自然人群血清中的莱姆病IgG抗体。结果发观,确诊感染者(IgG抗体滴度≥1∶128)40人,确诊感染率12.9%;可疑感染者(IgG抗体滴度1∶64)29人,可疑感染率9.4%。在受检的48个自然村中,检出有感染者的自然村17个,占35.4%。而不同性别、不同年龄及职业的确诊感染率差异均无显著性。另外,还调查了本病不同病期常见临床表现的流行率以及具有临床表现患者血清中IgG抗体情况。本次研究首次证实安徽省是莱姆病疫源地,并初步探讨了本病的流行特征。研究结果提示本病的分布可能非常广泛,人群对本病普遍易感。这将为本病的进一步研究与防治提供重要线索和依据。
Indirect immunofluorescence assay was used to detect Lyme disease IgG antibody in serum from 310 natural populations in a county of Dabie Mountain in Anhui Province. As a result, 40 people were diagnosed as infected (IgG antibody titer≥1: 128) and the rate of confirmed infection was 12.9%. Suspected infection (IgG antibody titer 1:64) was 29, and the suspicious infection rate was 9.4%. In the 48 natural villages examined, 17 villages with infected persons were detected, accounting for 35.4% of the total. There was no significant difference in the confirmed infection rates among different sexes, different ages and occupations. In addition, the prevalence of common clinical manifestations at different stages of the disease and the prevalence of IgG antibodies in the serum of patients with clinical manifestations were also investigated. This study for the first time confirmed that Anhui Province is the source of Lyme disease and preliminarily explored the epidemiological characteristics of this disease. The results suggest that the distribution of the disease may be very broad, the general population susceptible to the disease. This will provide important clues and basis for the further study and prevention of this disease.