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目的探讨替吉奥联合奥沙利铂治疗晚期胃癌的近期疗效以及护理干预对治疗顺利进行的作用。方法入组28例经病理学确诊的晚期胃癌患者，均接受替吉奥联合奥沙利铂治疗，观察其近期疗效及毒副反应，并针对常见毒副反应给出相应的护理干预，总结护理经验。结果全组28例晚期胃癌患者中，CR 1例，PR 14例，SD 8例，PD 5例，总有效率为53.57%，主要毒副反应包括周围神经毒性、骨髓抑制、胃肠道反应、口腔黏膜炎、静脉炎及皮疹等，但大多为轻度，经对症处理后均可缓解。结论在精心护理干预的情况下，采取替吉奥联合奥沙利铂方案治疗晚期胃癌安全有效。“,”Objective To investigate the short-term ef icacy and nursing interventions of S-1 combined with oxaliplatin for patients with advanced gastric cancer. Methods 28 patients with advanced gastric cancer underwent S-1 combined with oxaliplatin, the ef icacy and toxicities were observed, and the cor esponding nursing interventions for common toxicities were recorded. Results Al the 28 patients with advanced gastric cancer, CR was observed in the 1 case, PR in the 14 cases, SD in the 8 cases, PD in the 5 cases, the total ef ective rate was 53.57%, the main toxicities were peripheral neurotoxicity, bone mar ow suppression, gastrointestinal reactions, oral mucositis, phlebitis and rash, but were mostly mild, and could be al eviated after symptomatic treatment. Conclusion After intensive care intervention, S-1 combined with oxaliplatin is safe and ef ective for the patients with advanced gastric cancer.