Human equivalent dose of oral 4-aminopyridine differentiates nerve crush injury from transection inj

• 作 者: Chia George Hsu M A Hassan Tal
• 机 构: CenterforOrthopaedicResearchandTranslationalScience,DepartmentofMedicine,DepartmentofOrthopedics,Dep
• 出 处: 中国神经再生研究:英文版
• 发表日期: 2020年11期
• 关键词: 4-AMINOPYRIDINE electron microscopy of nerves functional recovery gene expressio
• 基金项目: supported by grants from the National Institutes of Health(NIH,K08 AR060164-01A),the Department of Defense(DoD,W81XWH-16-1-0725)to JCE,institutional support from the University of Rochester and Pennsy

4-Aminopyridine(4-AP), an FDA-approved drug for the symptomatic treatment of multiple sclerosis, is used to improve neuromuscular function in patients with diverse demyelinating disorders. We recently demonstrated that local, transdermal or injectable for