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[目的]了解农村地区惊厥型癫痫患者苯巴比妥单药治疗的有效性及安全性。[方法]对绵阳市游仙区、三台县农村地区惊厥型癫痫患者服用苯巴比妥,观察其疗效、不良反应、依从性并对其数据进行统计分析。[结果]纳入患者555例,69.2%的患者治疗前确诊为癫痫;77.7%的患者未规律服药,22.3%的患者从未治疗过;仅5.8%的患者接受了正规治疗。服用苯巴比妥的总有效率达68.4%;前3月存在严重不良反应,随服药时间延长不良反应明显减轻;服药第4月后依从性在90%以上。共160例患者不同时期退组,其退组主要原因有疗效差、失访、拒绝服药。[结论]农村地区癫痫患者诊断及治疗现状不容乐观,接受正规治疗比例极少;苯巴比妥单药治疗惊厥型癫痫表现出良好的治疗效果及安全性,以后工作中需加强对患者依从性和癫痫科普知识普及的管理。
[Objective] To understand the efficacy and safety of phenobarbital monotherapy in patients with convulsion-type epilepsy in rural areas. [Methods] Phenobarbital was taken in patients with convulsion-type epilepsy in Youxian district and Santai county in Mianyang city. The curative effect, adverse reaction and compliance were observed and their data were statistically analyzed. [Results] Among the 555 patients, 69.2% were diagnosed as epilepsy before treatment, 77.7% did not take medication regularly, 22.3% never treated and only 5.8% received formal treatment. The total effective rate of taking phenobarbital reached 68.4%. There were serious adverse reactions in the first 3 months, and the adverse reactions were relieved with the prolongation of medication duration. The compliance rate was above 90% after 4 months. A total of 160 patients retreated at different times, the main reason for the withdrawal group with poor efficacy, loss of follow-up, refused to take medicine. [Conclusion] The status of diagnosis and treatment of epilepsy patients in rural areas is not optimistic, and the proportion of receiving regular treatment is extremely low. Phenobarbital monotherapy in treating epilepsy shows good therapeutic effect and safety. And popularization of epilepsy popular science knowledge management.