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本文由四个医疗中心收集的病例进行对照性研究,其目的在于确定口服避孕药(OCs)是否增加分泌催乳素垂体腺瘤发生的危险。近十几年来,由于免疫学和生物学的应用,改进了测定人类外周血催乳素浓度的方法,在许多闭经和溢乳的妇女中已被证明垂体氨基酸复合物是升高的,而且藉助于放射线技术也比较容易识别这些妇女是否有分泌催乳案的垂体腺瘤存在。血液中雌激素浓度之增加,可为内源性或外源性因素引起。内源性雌激素浓度升高和垂体腺瘤发生的关系已由人类在整个妊娠期间垂体肥大所证
This is a controlled study of cases collected from four centers to determine whether oral contraceptives (OCs) increase the risk of prolactin-producing pituitary adenomas. For more than a decade, methods of determining prolactin concentrations in human peripheral blood have been improved due to immunological and biological applications and have been shown to be elevated in many women with amenorrhea and galactorrhea, with the aid of radiation The technique is also easier to identify if these women have pituitary adenomas secreting prolactin. The estrogen concentration in the blood increases, can be caused by endogenous or exogenous factors. The relationship between elevated endogenous estrogen levels and the development of pituitary adenomas has been documented by humans during the entire pregnancy