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采用酶联免疫双抗体夹心法动态监测39例肾移植患者术后血浆肿瘤坏死因子（TNF）的浓度，发现TNF水平在发生感染和急性排斥时显著增高，较临床症状的出现早1～2天，术后平稳患者及急性肾功能衰竭患者无明显变化，排斥者在应用甲基强的松龙冲击有效时TNF下降，在应用抗胸腺细胞球蛋白和单克隆抗体治疗的排斥患者中，首次用药后TNF上升，随后下降，未降者排斥不能逆转。结果说明动态监测血浆TNF能预示排斥及感染的发生，对治疗效果及预后的判断也有重要价值。
The levels of plasma tumor necrosis factor (TNF) in 39 renal transplant recipients were dynamically monitored by enzyme-linked immunosorbent assay (ELISA) and found that the level of TNF was significantly increased in patients with infection and acute rejection, which was 1 to 2 days earlier than the clinical symptoms , Postoperative patients with stable and acute renal failure patients did not change significantly, exclusion of methylprednisolone in the effective impact of TNF decreased in the application of anti-thymocyte globulin and monoclonal antibody therapy in patients with rejection, the first time After the rise of TNF, then decline, not falling exclusion can not be reversed. The results show that dynamic monitoring of plasma TNF can predict the occurrence of rejection and infection, the treatment effect and prognosis of judgment is also of great value.