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目的探讨HPV16-E6蛋白和Survivin在宫颈鳞癌和宫颈上皮内瘤变组织中的表达以及在宫颈癌发生、发展中的作用。方法取宫颈鳞癌30例、宫颈上皮内瘤变90例(其中CINⅠ、CINⅡ、CINⅢ分别30例),采用免疫组化EnVision二步法检测标本中HPV16-E6和Survivin的表达,另取正常宫颈者10例为对照组。结果 HPV16-E6和Survivin在宫颈鳞癌及宫颈上皮内瘤变中的表达随宫颈病变进展而呈递增趋势,且二者呈正相关;HPV16-E6和Survivin在宫颈鳞癌中的表达与患者年龄,临床分期、病理分级、淋巴结转移无关。结论 HPV16-E6和Sur-vivin与宫颈癌的发生、发展密切相关。
Objective To investigate the expression of HPV16-E6 protein and Survivin in cervical squamous cell carcinoma and cervical intraepithelial neoplasia and their roles in the development and progression of cervical cancer. Methods 30 cases of cervical squamous cell carcinoma and 90 cases of cervical intraepithelial neoplasia (CINⅠ, CINⅡ, CINⅢ, 30 cases respectively) were enrolled in this study. The expression of HPV16-E6 and Survivin were detected by immunohistochemical EnVision two-step method. 10 cases as control group. Results The expression of HPV16-E6 and Survivin in cervical squamous cell carcinoma and cervical intraepithelial neoplasia showed an increasing trend with the progression of cervical lesions, and the positive correlation was found between HPV16-E6 and Survivin. The expression of HPV16-E6 and Survivin in cervical squamous cell carcinoma correlated with age, Clinical stage, pathological grade, lymph node metastasis has nothing to do. Conclusion HPV16-E6 and Sur-vivin are closely related to the occurrence and development of cervical cancer.